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KMID : 0861020110260040049
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Korea Journal of Herbology
2011 Volume.26 No. 4 p.49 ~ p.57
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The therapeutic effect of Drynariae Rhizoma in a mouse model of allergic asthma
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Kim Seung-Taik
Lee Jang-Cheon
Lee Young-Cheol
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Abstract
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Objective: Allergic asthma is a chronic airway disease that affects millions of people in the developed world.
The disease is characterized by concurring airway inflammation, Th2 cytokine production, increased mucus
secretion, airway hyperresponsiveness (AHR) to inhaled antigen, and pulmonary fibrosis. To investigate the
therapeutic and anti-asthmatic effects of Drynariae Rhizoma (DR), we examined the influence of DR on the
development of pulmonary eosinophilic inflammation and airway hyperresponsiveness in a mouse model of
allergic asthma.
Methods: In this study, BALB/c mice were systemically sensitized to ovalbumin (OVA) followed intratracheally,
intraperitoneally, and by aerosol allergen challenges. We investigated the effect of DR on airway
hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokine
production and OVA specific IgE production in a mouse model of asthma.
Results: In asthmatic mice, we found that DR?treated groups had suppressed eosinophil infiltration, allergic
airway inflammation and AHR by suppressing the production of IL-5, IL-13 and OVA specific IgE.
Conclusions: Our data suggest that the therapeutic mechanism by which DR effectively treats asthma is based
on reductions of Th2 cytokines (IL-5), eotaxin, OVA-specific IgE production and eosinophil infiltration.
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KEYWORD
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Drynariae Rhizoma, asthma, eosinophil, IL-5, CCR3, eotaxin
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